SYNTHESIS OF CALYCOTOMINE AND N-METHYLCALYCOTOMINE USING A PETASIS REACTION - POMERANZ-FRITSCH-BOBBITT CYCLIZATION SEQUENCE

[摘要]：The use of aminoacetaldehyde acetals as the amine components in the one-step, three-component Petasis reaction followed by the Pomeranz-Fritsch-Bobbitt cyclization has been shown to be a convenient and simple method for the synthesis of tetrahydroisoquinoline alkaloids. Using this method two alkaloids, calycotomine and N-methylcalycotomine hydrochlorides, have been prepared in 61% overall yield.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内