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[摘要]:The first enantioselective total synthesis of a polyhydroxylated macrolide, (+)-seimatopolide A, was achieved. The key reactions, Sharpless asymmetric dihydroxylation, Yamaguchi esterification, and ring-closing metathesis, provided easy access to the target molecule from L-aspartic acid. Further, the absolute stereochemistry of the natural product has also been revised. |
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