Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands

[摘要]：This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT1D receptor. The field of 5-HT1D agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT1D receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.

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