Synthesis and Antimicrobial Activity of New C-Furyl Glycosides Bearing Substituted 1,3,4-Oxadiazoles

[摘要]：New 2,5-disubstituted 1,3,4-oxadiazole derivatives bearing C-furyl glycoside moieties and their sugar hydrazone as well as their per-O-acetyl derivatives were synthesized starting from ethyl 2-[5-(3,4-dihydroxytetrahydrofuran-2-yl)-2-methylfuran-3-yl]-2-oxoacetat e. Heterocyclization of the sugar hydrazones using acetic anhydride afforded the corresponding oxadiazoline acyclic C-nucleosides. The antimicrobial activity evaluation showed that many of the synthesized compounds revealed moderate to high antimicrobial activity.

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