Efficient access to isoxazoles from alkenes.

[摘要]：The direct regioselective synthesis of 3,5-disubstituted isoxazoles was achieved in one reaction vessel through a sequence of reactions involving the net bromination of an electron-deficient alkene, in-situ generation of a nitrile oxide, 1,3-dipolar cycloaddn., and loss of HBr from an intermediate 5,5-disubstituted bromoisoxazoline. This one-pot process enables the synthesis of 3,5-disubstituted isoxazoles directly from electron-deficient alkenes thereby negating the isolation of the 1,1-disubstituted bromo-alkene alkyne surrogate.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内