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A Facile Synthesis of 6H-[1,3,5]Triazino[2,1-b]quinazolin-6-ones

  作者 ABBOTT SHAUN; CLOUTIER JOSEE; HOUDE KARINE; PENNEY CHRISTOPHER; ZACHARIE BOULOS  
  选自 期刊  Synthesis;  卷期  2011年-11;  页码  1733-1740  
  关联知识点  
 

[摘要]Triazinoquinazolinone derivatives are synthesized by cyclization of aminobenzamide-substituted triazine compounds in the presence of a proton source such as trifluoroacetic acid or hydrochloric acid. The reaction is mild, general, and gives high yield (> 90%) of the cyclized product. This procedure allows, for the first time, access to triazinoquinazolinone compounds bearing different functionalities on the benzene and triazine moieties that are not available by other routes.

 
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