Sequential Hydration-Condensation-Double Cyclization of Pyridine-Substituted 2-Alkynylanilines: An Efficient Approach to Quinoline-Based Heterocycles

[摘要]：An environmentally benign and atom-economical process to construct a unique quinoline-based tetracyclic scaffold, through sequential hydration-condensation-double cyclization reactions, has been described. The reaction starts with readily available pyridine-substituted o-alkynylanilines and beta-keto esters, promoted by p-toluenesulfonic acid in ethanol in one pot. In the absence of beta-keto esters, multisubstituted quinolines are formed bimolecularly in reasonable yields.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内