Improved Protocol for Indoline Synthesis via Palladium-Catalyzed Intramolecular C(sp(2))-H Amination

[摘要]：An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected beta-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp(2))-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.

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