Synthesis of Furanoid Amino Acids via a Domino Michael-Aldol-Addition-Cyclization Approach

[摘要]：Chelated enolates undergo Michael addition towards halogenated alpha,beta-unsaturated esters in a highly stereoselective fashion. The enolates formed can be trapped with aldehydes in a stereoselective aldol reaction, before subsequent cyclization gives rise to substituted furanoid amino acids. Up to for stereogenic centers can be formed in this new one-pot reaction.

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