Palladium-Catalyzed Cross-Coupling of Sterically Demanding Boronic Acids with alpha-Bromocarbonyl Compounds

[摘要]：A catalyst system generated in situ from Pd(dba)(2) and tri(o-toly)phosphine mediates the coupling of arylboronic acids with alkyl alpha-bromoacetates under formation of arylacetic acid esters at unprecedented low loadings. The new protocol, which involves potassium fluoride as the base and catalytic amounts of benzyltriethylammonium bromide as a phase transfer catalyst, is uniquely effective for the synthesis of sterically demanding arylacetic acid derivatives.

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