Indium-Mediated Aza-Henry Reaction of Imines: Access to 2-Nitroamines

[摘要]：A new method has been developed to obtain 2-nitroamines by an indium-promoted reaction of bromonitromethane with a variety of imines. On the strength of these results, the reaction was also performed with 2-bromo-2-nitropropanes to afford 2,2-dialkyl-2-nitroamines. Moreover, the indium-mediated reaction of 1-bromo-1-nitroethane and imines afforded 1-methyl-2-nitroamines with remarkably high anti selectivity. The use of chiral sugar-derived imines furnished the corresponding 2-nitroamines with excellent stereoselectivity.

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