[摘要]：This paper reports the chemical study of a sample of Fasciospongia sp. collected along the Atlantic Portuguese coast. Three new isomeric furanosesquiterpenes, isomicrocionin-3 (1), (-)-microcionin-1 (2), and (-)-isomicrocionin-1 (3), were isolated along with the known (-)-ent-pallescensin A (4) and (-)-pallescensin-1 (5) from the ethyl acetatesoluble portion of the methanolic extract. The structures of the new compounds were elucidated by extensive spectroscopic studies. (-)-Microcionin-1 (2) tested positive against several Gram-negative bacteria.
