A Cell Wall-Active Lipopeptide from the Fungus Pochonia bulbillosa

[摘要]：Bioassay-directed fractionation of a fermentation of Pochonia bulbinosa, culture 386272, led to the isolation of a series of structurally novel, prospective cell wall-active lipopeptides. The main component of this suite is 1, a linear hexapeptide with a delta-hydroxymyristic acid amide substituted N-terminus. The structure was deduced using high-field microsample NMR. Fourier transform mass spectrometry, and microscale chemical degradation. The potent cell wall activity and synthetically accessible structure of 1 make it a potential lead for further investigation.

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