【文章名】The Reaction of N-Isocyaniminotriphenylphosphorane with Ester Derivatives of 2-Oxopropyl Alcohol (2-Oxopropyl 4-Bromobenzoate, 2-Oxopropyl Benzoate, and 2-Oxopropyl Acetate) in the Presence of Aromatic Carboxylic Acids: A One-Pot Efficient Three-Component Reaction for the Synthesis of Fully Substituted 1,3,4-Oxadiazole Derivatives
The Reaction of N-Isocyaniminotriphenylphosphorane with Ester Derivatives of 2-Oxopropyl Alcohol (2-Oxopropyl 4-Bromobenzoate, 2-Oxopropyl Benzoate, and 2-Oxopropyl Acetate) in the Presence of Aromatic Carboxylic Acids: A One-Pot Efficient Three-Component Reaction for the Synthesis of Fully Substituted 1,3,4-Oxadiazole Derivatives
[摘要]：Reactions of N-isocyaniminotriphenylphosphorane with ester derivatives of 2-oxopropyl alcohol (2-oxopropyl 4-bromobenzoate, 2-oxopropyl benzoate, and 2-oxopropyl acetate) in the presence of aromatic carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed.
