[摘要]：beta-Hairpin peptidomimetics mimicking the interaction sites of the platelet receptor glycoprotein (GP)Ib alpha with von Willebrand factor (vWF) were synthesised and evaluated for their ability to increase platelet velocity under high shear conditions and to inhibit shear-induced platelet aggregation. A cyclic and bridged dodecapeptide 2e containing a heterochiral diproline motif was identified as a lead compound for the generation of a novel class of potential antiplatelet agents. (C) 2012 Elsevier Ltd. All rights reserved.
