Reductive Ring Cleavage of Nonconjugated Delta(2)-Isoxazolines to beta-Hydroxy Ketones with Aluminum and Copper(II) Chloride

[摘要]：A facile, economic, and efficient protocol for the reduction of nonconjugated Delta(2)-isoxazolines to the corresponding beta-hydroxy ketones using Al/CuCl2 as the reducing agent has been developed. The method is both rapid and complete requiring less than ten minutes to attain total ring cleavage. This is the first example of using an in situ prepared Al/Cu couple in organic synthesis.

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