Improved Synthesis of 2-Chloro-3-amino-4-methylpyridine

[摘要]：2-Chloro-3-amino-4-methylpyridine (), a key intermediate in the synthesis of nervirapine, was prepared from 2-cyanoacetamide and 4,4-dimethoxyl-2-butanone via condensation, cyclization, one-pot reaction of chlorination and hydrolysis, and Hofmann reaction. Utilization of the quadratic orthogonal test resulted in a high yield (62.1%) of the whole process.

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