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Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin-nicotinamide cocrystal by solid-state NMR

  作者 MARUYOSHI KEISUKE; IUGA DINU; ANTZUTKIN OLEG N; ALHALAWEH AMJAD; VELAGAD SITARAM P; BROWN STEVEN P  
  选自 期刊  Chemical Communications;  卷期  2012年48-88;  页码  10844-10846  
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[摘要]Two-dimensional H-1 double-quantum and N-14-H-1 & H-1-C-13 heteronuclear magic-angle spinning (MAS) NMR spectra recorded at natural isotopic abundance identify specific intermolecular COOH center dot center dot center dot N-arom and CHarom center dot center dot center dot O=C hydrogen-bonding interactions in the solid-state structure of an indomethacin-nicotinamide cocrystal, thus additionally proving cocrystal formation.

 
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