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Selective Synthesis of Cyano-Functionalized 2-Aryl-4H-chromenes and 2-Amino-4H-chromene-3-carbonitriles by Catalyst-Tuned Reactions of 2-Hydroxychalcones with 2-Substituted Acetonitriles

  作者 YIN GUODONG; SHI HOUQIANG; XU LIQIANYUN; WEI XIANHONG; TAO QING  
  选自 期刊  Synthesis;  卷期  2013年45-3;  页码  334-340  
  关联知识点  
 

[摘要]A selective synthesis of 4H-chromenes by the reactions of 2-hydroxychalcone derivatives with acetonitriles substituted with electron-withdrawing groups is described. Under catalyst-free conditions, the reactions give cyano-functionalized 2-aryl-4H-chromenes, whereas in the presence of sodium bicarbonate, 2-amino-4H-chromene-3-carbonitriles are obtained in excellent yields.

 
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