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Isoxazoles incorporated N-substituted decahydroquinolines: A precursor to the next generation antimicrobial drug

  作者 Babu, M; Pitchumani, K; Ramesh, P  
  选自 期刊  European Journal of Medicinal Chemistry;  卷期  2012年47-1;  页码  608-614  
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[摘要]We report here a simple entry into N-substituted decahydroisoxazoloquinoline system with substituents at position 3 and 4 from the readily available substrates for the first time. The synthesized iso-xazoloquinolines were evaluated against six bacterial and four fungal strains. The results suggest that the decahydroisoxazolo[4,3-c]quinoline scaffold has the potential to be developed into therapeutically useful antimicrobial agents. (C) 2011 Elsevier Masson SAS. All rights reserved.

 
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