Asymmetric [3+2] Cycloaddition of Azomethine Ylides Catalyzed by Silver(I) Triflate with a Chiral Bipyrrolidine-Derived Phosphine Ligand

[摘要]：Two novel chiral bipyrrolidine-derived phosphine ligands L1 and L2 were synthesized. The 'AgOTf+L1' protocol catalyzes the asymmetric [3+2] cycloaddition of azomethine ylides with alkenes to give highly substituted pyrrolidines in good yields (up to 90%) with moderate to high diastereoselectivities (up to > 19:1 dr) and enantioselectivities (up to 76%).

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