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[摘要]：Combretastatin is a vascular disrupting agent that has been very effective in disrupting tumor blood flow, resulting in enhanced tumor killing. Combretastatin may have detrimental effects on normal tissue, so analogues with the same properties as combretastatin are being developed in an effort to find the ideal drug that destroys all types of tumors while having no deleterious effects in normal tissue. This review focuses on a select few derivatives of combretastatin developed in the past few years that have shown some such promise. These drugs have passed quality tests in cell culture or in implanted tumor models. The compounds reviewed have been effective in causing various cancer cell lines to undergo apoptosis in culture, or in completely shutting down tumor blood flow in implanted tumor models. The majority of successful drug analogues have been more effective than combretastatin in either killing capacity or normal tissue sparing, or a combination of both. Some drugs have even resulted in complete tumor regression. |
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