Synthesis of 6,7,8-Trisubstituted Purines via a Copper-Catalyzed Amidation Reaction.

[摘要]：An efficient method for the synthesis of 6,7,8-trisubstituted purines, i.e. I, via a copper-catalyzed amidation reaction from easily accessible starting materials is reported. Furthermore, the resulting 6-benzylsulfanyl-substituted purine derivs. may be readily oxidized for substitution by nucleophiles to give access to 6,7,8- trisubstituted purines for biol. screening purposes.

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