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IMPROVED SYNTHESIS OF 1-OXO-1,2,3,4-TETRAHYDROACRIDINE-9-CARBOXYLIC ACIDS FROM ISATINS AND 1,3-CYCLOHEXANEDIONE

  作者 LV QINGHUA; FANG LIZHEN; LU CHENJUAN; WANGL PENGFEI  
  选自 期刊  Heterocycles;  卷期  2012年85-6;  页码  1457-1463  
  关联知识点  
 

[摘要]An improved protocol for the preparation of 1-oxo-1,2,3,4-tetrahydroacridine-9-carboxylic acid derivatives via Pfitzinger condensation under acidic conditions is described, it provides a simple one-pot synthetic method for some useful 1-oxo-1,2,3,4-tetrahydroacridine-9-carboxylic acids which could not be synthesized successfully by Pfitzinger reactions under usual conditions using the corresponding isatins and 1,3-diketones. All the synthesized compounds are characterized by spectral data.

 
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