Synthesis and Antibacterial Activity of Bicyclic Lactam-Lactones

[摘要]：The synthesis of a lactam-lactone bicyclic system containing a pyroglutamate subunit proceeds to give the fused lactone system, which is favoured over the spirocyclic lactone alternative. These systems display no or weak antibacterial activity against the test organisms S. aureus and E. coli.

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