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[摘要]:Benzopyran-annulated thiopyrano[2,3-b] thiochromen-5(4H)-ones have been synthesized by the domino Knoevenagelhetero-Diels-Alder (DKHDA) reaction of 4-hydroxydithiocoumarin with O-allylated salicylaldehyde and O-propargylated salicylaldehyde in aqueous medium. The reaction requires only a single step operation and is highly regio- and stereoselective providing potentially bioactive polycyclic heterocycles in high yields. |
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