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Green Synthesis of Benzopyran-Annulated Thiopyrano[2,3-b]thiochromen-5(4H)-ones by Domino Knoevenagel-Hetero-Diels-Alder Reaction

  作者 MAJUMDAR K C; TAHER ABU; PONRA SUDIPTA  
  选自 期刊  Synthesis;  卷期  2010年-23;  页码  4043-4050  
  关联知识点  
 

[摘要]Benzopyran-annulated thiopyrano[2,3-b] thiochromen-5(4H)-ones have been synthesized by the domino Knoevenagelhetero-Diels-Alder (DKHDA) reaction of 4-hydroxydithiocoumarin with O-allylated salicylaldehyde and O-propargylated salicylaldehyde in aqueous medium. The reaction requires only a single step operation and is highly regio- and stereoselective providing potentially bioactive polycyclic heterocycles in high yields.

 
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