| |
[摘要]：Aim: To determine the efficacy of preoperative weekly paclitaxel for patients with operable breast cancer tumors greater than 3 cm. Patients and Methods: Paclitaxel 80 mg/m(2) weekly x 3 times every 4 weeks for 3 cycles was administered to 53 patients. Twnty-two patients were stage 11, 26 stage III, 5 stage IV. Median age (range) was 53 (24-73)years, and 32 patients were negative for estrogen receptor. Thirteen patients showed HER2 overexpression. Results: Eligible cases composed of 53 patients for evaluation of response. Seven patients had a clinical complete response and 29 patients had a partial response. The overall response rate was 67.9%, including three patients with a pathological complete response. In 18 patients with HER2 overexpression, a clinical complete response was observed in 5, a partial response was observed in 9, and stable disease was found in 4. No treatment, related to grade 3 neutropenia, was given for 1 patient (2%). Other hematological and nonhematological toxicity was found in only I patient with fatigue. Conclusion: Preoperative weekly paclitaxel induced a high clinical response rate with a high safety profile. HER2-overepressing tumors had a higher clinical response rate than non-HER2-overepxressing tumors (91% vs. 50%, respectively). Further studies are needed to determine whether an increase in the cycles of paclitaxel and/or adding anthracyclines may lead to higher pathological complete response and breast-conservation rates in the neoadjuvant setting. |
|
