【文章名】Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as a novel marker for the detection of peritoneal micrometastasis
Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as a novel marker for the detection of peritoneal micrometastasis
[摘要]：Background: Regenerating gene type TV (RegIV) is a candidate marker for cancer and inflammatory bowel disease. In this study, its potential as a novel marker for the detection of gastric cancer peritoneal micrometastases was examined. Patients and Methods: RegIV mRNA levels in the peritoneal washes of 95 gastric cancer patients and 22 with benign disease were quantified by real-time RT-PCR. To examine whether expression of RegIV enhance tumorigenicity or not, thirty two mice were injected intraperitoneally or subcutaneously with RegIV transfectants of TMK-1 cells, parental TMK-1 cells, or neomycin control transfectants. Results: RegIV expression was markedly higher in patients with peritoneal metastases compared to those without. The level of RegIV mRNA in gastric cancer patients was related to the extent of wall penetration. A cut-off value for RegIV-positive.
