Reaction between N-Isocyaniminotriphenylphosphorane, Aldimines, Meldrum's Acid and Water: Diastereoselective Synthesis of 3,4-Disubstituted N-Aminopyrrolidine-2,5-diones

[摘要]：A multicomponent synthesis of 3,4-disubstituted N-aminopyrrolidine-2,5-diones is described. A mixture of N-isocyaniminotriphenylphosphorane, an aldimine and Meldrum's acid undergoes an addition reaction under mild conditions in aqueous THF to produce 1-amino-4-aryl-2,5-dioxo-N-3-aryl-3-pyrrolidinecarboxamides diastereoselectively in good to excellent yields. H-1 NMR analysis showed that the two substituents on C-3 and C-4 positions of the obtained pyrrolidine-2,5-diones are trans.

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