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An Expedient Access to Still-Gennari Phosphonates

  作者 MESSIK FRAUKE; OBERTHUER MARKUS  
  选自 期刊  Synthesis;  卷期  2013年45-2;  页码  167-170  
  关联知识点  
 

[摘要]An inexpensive and efficient route to the Still-Gennari phosphonates, methyl and ethyl bis(2,2,2-trifluoroethyl)phosphonoacetates, has been developed. This short reaction sequence is operationally simple and makes these versatile reagents for the preparation of Z-alkenes, according to the Still-Gennari modification of the Horner-Wadsworth-Emmons olefination reaction, available in multigram quantities.

 
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