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[摘要]：Overexpression of cyclooxygenase-2 (COX-2) has been implicated as a tumor-initiating and -promoting event for a number of common solid tumors, including lung, breast and colon cancer. Considerable epidemiological evidence supports COX-2 inhibition as a method of chemoprevention. Inhibition of COX-2 in laboratory models has been demonstrated to be antineoplastic both by itself and in combination with cytotoxic and targeted agents. Apricoxib is a novel, potent and selective inhibitor of COX-2 currently under development as an anti-cancer agent, as well as an analgesic. This review discusses the pharmacology, preclinical and clinical results with apricoxib, focusing on its potential use in oncology. |
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