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Sequential Reactions with Grubbs Catalyst and AD-mix-a/b Using PDMS Thimbles.

  作者 Mwangi, Martin T.;Schulz, Michael D.;Bowden, Ned B.;  
  选自 期刊  Organic Letters;  卷期  2009年11-1;  页码  33-36  
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[摘要]Incompatible Grubbs catalyst and an osmium dihydroxylation catalyst were site-isolated from each other using polydimethylsiloxane thimbles. The Grubbs catalyst was added to the interior of the thimbles, and AD-mix-a/b was added to the exterior. Org. substrates readily fluxed through the walls of the thimbles and reacted with each catalyst. A series of cascade reactions were developed including those with intermediates possessing low b.ps. or that were foul smelling.

 
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