Pyrazole NNRTIs 1: Design and initial optimisation of a novel template

[摘要]：The design and synthesis of a novel series of non-nucleoside HIV reverse transcriptase inhibitors (NNR-TIs) based on a pyrazole template is described. These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants. (C) 2009 Elsevier Ltd. All rights reserved.

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