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A Tandem One-Pot, Microwave-Assisted Synthesis of Regiochemically Differentiated 1,2,4,5-Tetrahydro-1,4-benzodiazepin-3-ones.

  作者 De Silva, Ravindra A.;Santra, Soumava;Andreana, Peter R.;  
  选自 期刊  Organic Letters;  卷期  2008年10-20;  页码  4541-4544  
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[摘要]A one-pot, two-step synthesis of the title compds. employs a multicomponent Ugi condensation reaction, microwave irradn., and Fe(0) as a reductant. Two pathways are accessible; both routes utilize bifunctional, o-nitro-substituted arenes leading to either C2, N4, C5 substitution or C2, N4 substitution.

 
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