Synthesis and Fungicidal Activity of 1,3-Thiazoline Derivatives Bearing Nitrophenyl Group on the 2-Position

[摘要]：Ortho-, meta-, or para-nitro benzoic acid were refluxed with excess SOCl2 to give acyl chloride, which condensed with beta-amino alcohol in the presence of Et3N in dichloromethane to afford beta-hydroxyamide; finally, sulphonation and cyclization were simultaneously conducted to afford 1,3-thiazoline derivatives. Fungicidal activity of these new thiazolines against eight agrocultural fungi were evaluated, and two of this type of compounds displayed good fungicidal activity comparable or superior to commercial fungicide chlorothalonil against two fungi at a concentration of 50 mg/L.

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