Polycyclic N-Heterocyclic Compounds. Part 66: Synthesis of N-[2-([1,2,4]Oxadiazol-5-yl)cyclopenten-1-yl]formamide Oximes and Their Evaluation as Inhibitors of Platelet Aggregation [1]

[摘要]：N-[2-([1,2,4]Oxadiazol-5-yl)cyclopenten-1-yl]formamide oximes were synthesized by fusion of (6,7-dihydro-5H-cyclopenta[1,2-d]pyrimidin-4-yl)amidines and/or their amide oximes with hydroxylamine hydrochloride through a subsequent rearrangement reaction. Assay of the products for anti-platelet aggregation activity revealed that certain of them showed promising inhibitory effect on arachidonic acid-induced platelet aggregation.

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