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Polymer-Supported Pentaethylene Glycol as a Facile Heterogeneous Catalyst for Nucleophilic Fluorination

  作者 JADHAV VINOD H; JANG SEUNG HO; JEONG HWANJEONG; LIM SEOK TAE; SOHN MYUNGHEE; CHI DAE YOON; KIM DONG WOOK  
  选自 期刊  Organic Letters;  卷期  2010年12-17;  页码  3740-3743  
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[摘要]Polymer-supported pentaethylene glycols (PSpentaEG) as promising catalysts for nucleophilic fluorination with alkali metal fluoride (MF) could significantly enhance the nucleophilicity of MF and provide simple purification and recycling in the reaction. Furthermore, by their synergistic effect, the combination of PSpentaEG and a tert-alcohol media system showed tremendous efficiency in the fluorination of base-sensitive substrates such as sec-alkyl halide.

 
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