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The Joy of Six: How to Control Your Crossovers

  作者 Globus, ST; Keeney, S  
  选自 期刊  Cell;  卷期  2012年149-1;  页码  11-12  
  关联知识点  
 

[摘要]Meiotic cells tightly regulate the number and distribution of crossovers to promote accurate chromosome segregation. Yokoo and colleagues uncover a metazoan-specific, cyclin-like protein that is crucial for crossover formation. They utilize this protein's unique properties to explore a remarkable example of biological numerology, whereby nearly every meiotic cell in C. elegans makes precisely six crossovers, one for each of its six chromosome pairs.

 
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