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Inhibitors of the Oncogenic Transcription Factor AP-1 from Podocarpus latifolius

  作者 Devkota, KP; Ratnayake, R; Colburn, NH; Wilson, JA; Henrich, CJ; McMahon, JB; Beutler, JA  
  选自 期刊  Journal of natural products;  卷期  2011年74-3;  页码  374-377  
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[摘要]An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation, of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity.

 
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