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One-Pot, Three-Component Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Starting from Primary Alcohols

  作者 JIN GUANYI; ZHANG JIAN; FU DAN; WU JINGJING; CAO SONG  
  选自 期刊  European Journal of Organic Chemistry;  卷期  2012年-28;  页码  5446-5449  
  关联知识点  
 

[摘要]A novel, one-pot, three-component approach for the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles through the cycloaddition of a wide range of primary alcohols with sodium azide and active methylene ketones in the presence of N-(p-toluenesulfonyl)imidazole, tetrabutylammonium iodide, and triethylamine in DMF/DMSO has been developed.

 
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