Synthesis and Antimicrobial Activities of New Polyhalogenated Benzimidazoles

[摘要]：A series of new polyhalogenated benzimidazoles has been synthesized and their antibacterial and antiprotozoal activity was evaluated. Several of new substituted halogenobenzimidazoles and their 2'-deoxynucleosides showed noteworthy antiprotozoal toxicity particularly against Giardia lamblia. The most potent agents against bacteria and fungi were 4,5,6,7-tetrachlorobenzimidazoles with polyfluoroalkyl chain at position 2 of the heterocyclus.

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