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Electrophilic Iodo-Mediated Cyclization in PEG under Microwave Irradiation: Easy Access to Highly Functionalized Furans and Pyrroles

  作者 SPINA ROSELLA; COLACINO EVELINA; GABRIELE BARTOLO; SALERNO GIUSEPPE; MARTINEZ JEAN; LAMATY FREDERIC  
  选自 期刊  SYNLETT;  卷期  2012年-10;  页码  1481-1484  
  关联知识点  
 

[摘要]The rapid and facile synthesis of highly substituted beta-iodofurans and beta-iodopyrroles is reported using a mixture of molecular iodine and a base in solid PEG 3400 as alternative, eco-friendly and nontoxic solvent under microwave irradiation, in a very short time. The heterocycles are efficiently recovered in good yields by a simple workup procedure, avoiding chromatographic purification.

 
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