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A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2 '-quinoline] Scaffold

  作者 SHI FENG; XING GUIJUAN; ZHU RENYI; TAN WEI; TU SHUJIANG  
  选自 期刊  Organic Letters;  卷期  2013年15-1;  页码  128-131  
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[摘要]The first catalytic asymmetric isatin-involved Povarov reaction has been established. This method provides an unprecedented approach to access the enantioenriched spiro[indolin-3,2'-quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stereoselectivities (all >99:1 drs, up to 97% ee).

 
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