[摘要]：The synthesis of spiro nitrone I via microwave-assisted intramol. alkylation of 1-(4-bromobutyl)cyclohexanal oxime is reported. The bromo oxime is prepd. by alkylation of cyclohexanecarboxylate with Br(CH2)4Br followed by conversion of the ester to an oxime. Spiro nitrone I undergoes facile 1,3-dipolar cycloaddn. to a range of olefins to form a range of spirocyclic isoxazolidines. Nucleophilic addn. of several Grignard reagents to I provided access to a series of alkyl-substituted spiro hydroxylamines.
