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Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase

  作者 Vashisht, AA; Zumbrennen, KB; Huang, XH; Powers, DN; Durazo, A; Sun, DH; Bhaskaran, N; Persson, A; Uhlen, M; Sangfelt, O; Spruck, C; Leibold, EA; Wohlschlegel, JA  
  选自 期刊  Science;  卷期  2009年326-5953;  页码  718-721  
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[摘要]Eukaryotic cells require iron for survival and have developed regulatory mechanisms for maintaining appropriate intracellular iron concentrations. The degradation of iron regulatory protein 2 (IRP2) in iron-replete cells is a key event in this pathway, bu

 
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