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An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis

  作者 Salahudeen, AA; Thompson, JW; Ruiz, JC; Ma, HW; Kinch, LN; Li, QM; Grishin, NV; Bruick, RK  
  选自 期刊  Science;  卷期  2009年326-5953;  页码  722-726  
  关联知识点  
 

[摘要]Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of genes responsible for iron uptake, release, use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2. However, the manner in which iron l

 
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