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Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift

  作者 Hensley, SE; Das, SR; Bailey, AL; Schmidt, LM; Hickman, HD; Jayaraman, A; Viswanathan, K; Raman, R; Sasisekharan, R; Bennink, JR; Yewdell, JW  
  选自 期刊  Science;  卷期  2009年326-5953;  页码  734-736  
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[摘要]Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza vaccine. Neutralizing antibodies selected mutants wi

 
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