MICROWAVE-ASSISTED MULTICOMPONENT REACTION IN WATER: HIGHLY STEREOSELECTIVE SYNTHESIS OF PYRIMIDINESPIROISOXAZOLO[5,4-b]PYRIDINE DERIVATIVES

[摘要]：A multicomponent reaction has been established for the synthesis of pyrimidinespiroisoxazolo[5,4-b]pyridines that can serve as versatile building blocks for both organic and medicinal research. The reasonable reaction mechanism has proposed to explain the resulting stereochemistry of products. The present green synthesis shows several advantages including operational simplicity and fast reaction rate, which makes it a useful and attractive process for library generation for drug discovery.

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