An Improved Synthesis of 2-, 3-, and 4-(Trifluoromethyl)cyclohexylamines

[摘要]：An improved synthesis of 2-, 3-, and 4-trifluoromethyl-cyclohexylamines on a multigram scale via PtO2-mediated hydrogenation of the corresponding trifluoromethylanilines in trifluoroacetic acid at room temperature under atmospheric pressure is reported. The hydrogenation occurred with a remarkable stereo-selectivity favoring the formation of cis-isomers.

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