ITERATIVE ONE POT REACTIONS OF A CHIRAL SULFAMIDATE WITH 2,4,6-TRICHLOROPYRIDINE: REGIOCONTROLLED SYNTHESIS OF LINEAR AND ANGULAR CHIRAL DIPYRROLIDINO PYRIDINES

[摘要]：The product of the ring opening of a chiral sulfamidate with the 3-lithiopyridine species obtained by deprotonation of 2,4,6-trichloropyridine with n-BuLi can be deprotonated again in situ with n-BuLi and reacted with a second equivalent of the sulfamidate furnishing a bis beta-aminoethyl pyridine derivative which can be cyclized regioselectively to linear or angular chiral dipyrrolidino pyridines.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内